235 research outputs found
Seasonal variations of the serum proteins in sheep and goats (Short Communication)
Abstract. The aim of this study was to assess the seasonal trend of the serum protein content of sheep and goats. The tested animals were six female goats (Maltese breed) and six female sheep (Valle del Belice breed). All animals were clinically healthy and not pregnant or lactating before or during the study. On blood samples, collected through an external jugular venipuncture every 30 days for 12 months, electrophoresis was performed using a semiautomated AGE system and then electrophoretic curves with the relative protein concentrations were analyzed. One way for repeated measure analysis of variance (ANOVA) was applied to determine the effect of time and by means of cosinor rythmometry, mesor (mean level), amplitude (half the range of oscillation) and acrophase (Φ, time of peak) were determined. The results showed a seasonal rhythm on Albumin and Alumin/Globulin ratio for sheep and goats, with different acrophases, winter for goats and spring for sheep. A seasonal rhythm was shown also in Alpha 2 globulins by sheep and in Beta globulins by goats. The difference in the acrophase can be attributed to a different production pattern of melatonin in goat, so the liver production of albumin is major during the winter that has a longer scotophase
Efficient conversion of chemical energy into mechanical work by Hsp70 chaperones
Hsp70 molecular chaperones are abundant ATP-dependent nanomachines that
actively reshape non-native, misfolded proteins and assist a wide variety of
essential cellular processes. Here we combine complementary
computational/theoretical approaches to elucidate the structural and
thermodynamic details of the chaperone-induced expansion of a substrate
protein, with a particular emphasis on the critical role played by ATP
hydrolysis. We first determine the conformational free-energy cost of the
substrate expansion due to the binding of multiple chaperones using
coarse-grained molecular simulations. We then exploit this result to implement
a non-equilibrium rate model which estimates the degree of expansion as a
function of the free energy provided by ATP hydrolysis. Our results are in
quantitative agreement with recent single-molecule FRET experiments and
highlight the stark non-equilibrium nature of the process, showing that Hsp70s
are optimized to convert effectively chemical energy into mechanical work close
to physiological conditions
Wisdom of groups promotes cooperation in evolutionary social dilemmas
Whether or not to change strategy depends not only on the personal success of
each individual, but also on the success of others. Using this as motivation,
we study the evolution of cooperation in games that describe social dilemmas,
where the propensity to adopt a different strategy depends both on individual
fitness as well as on the strategies of neighbors. Regardless of whether the
evolutionary process is governed by pairwise or group interactions, we show
that plugging into the "wisdom of groups" strongly promotes cooperative
behavior. The more the wider knowledge is taken into account the more the
evolution of defectors is impaired. We explain this by revealing a dynamically
decelerated invasion process, by means of which interfaces separating different
domains remain smooth and defectors therefore become unable to efficiently
invade cooperators. This in turn invigorates spatial reciprocity and
establishes decentralized decision making as very beneficial for resolving
social dilemmas.Comment: 8 two-column pages, 7 figures; accepted for publication in Scientific
Report
Different reactions to adverse neighborhoods in games of cooperation
In social dilemmas, cooperation among randomly interacting individuals is
often difficult to achieve. The situation changes if interactions take place in
a network where the network structure jointly evolves with the behavioral
strategies of the interacting individuals. In particular, cooperation can be
stabilized if individuals tend to cut interaction links when facing adverse
neighborhoods. Here we consider two different types of reaction to adverse
neighborhoods, and all possible mixtures between these reactions. When faced
with a gloomy outlook, players can either choose to cut and rewire some of
their links to other individuals, or they can migrate to another location and
establish new links in the new local neighborhood. We find that in general
local rewiring is more favorable for the evolution of cooperation than
emigration from adverse neighborhoods. Rewiring helps to maintain the diversity
in the degree distribution of players and favors the spontaneous emergence of
cooperative clusters. Both properties are known to favor the evolution of
cooperation on networks. Interestingly, a mixture of migration and rewiring is
even more favorable for the evolution of cooperation than rewiring on its own.
While most models only consider a single type of reaction to adverse
neighborhoods, the coexistence of several such reactions may actually be an
optimal setting for the evolution of cooperation.Comment: 12 pages, 5 figures; accepted for publication in PLoS ON
Perforated acute appendicitis resulting from appendiceal villous adenoma presenting with small bowel obstruction: a case report
<p>Abstract</p> <p>Background</p> <p>A villous adenoma is an extremely rare benign tumour in the appendix, in contrast to other benign appendiceal lesions. The clinical features are usually asymptomatic. Acute appendicitis is the most common complication with the lesion obstructing the orifice of the appendiceal lumen. Thus, a villous adenoma is usually found during surgical intervention for acute appendicitis. Mechanical obstruction induced by acute perforated appendicitis has been previously reported. Acute appendicitis caused by a villous adenoma presenting with acute intestinal obstruction has not been previously reported.</p> <p>Case presentation</p> <p>A 78-year-old woman presented to our Emergency Department with diffuse abdominal pain and tenderness. The abdominal plain film and computed tomography revealed an intestinal obstruction. After surgical intervention, the ruptured appendix was shown to be associated with intestinal obstruction. The post-operative pathologic diagnosis was an appendiceal villous adenoma.</p> <p>Conclusions</p> <p>This is the first report describing an appendiceal villous adenoma, which is an occasional cause of perforated acute appendicitis, presenting as a complete intestinal obstruction. We emphasize that in elderly patients without a surgical history, the occult cause of complete intestinal obstruction must be determined. If an appendiceal tumour is diagnosed, an intra-operative frozen section is suggested prior to selecting a suitable method of surgical intervention.</p
Optimal interdependence between networks for the evolution of cooperation
Recent research has identified interactions between networks as crucial for the outcome of evolutionary
games taking place on them. While the consensus is that interdependence does promote cooperation by
means of organizational complexity and enhanced reciprocity that is out of reach on isolated networks, we
here address the question just how much interdependence there should be. Intuitively, one might assume
the more the better. However, we show that in fact only an intermediate density of sufficiently strong
interactions between networks warrants an optimal resolution of social dilemmas. This is due to an intricate
interplay between the heterogeneity that causes an asymmetric strategy flow because of the additional links
between the networks, and the independent formation of cooperative patterns on each individual network.
Presented results are robust to variations of the strategy updating rule, the topology of interdependent
networks, and the governing social dilemma, thus suggesting a high degree of universality
The plants, rituals and spells that 'cured' helminthiasis in Sicily
<p>Abstract</p> <p>Background</p> <p>The author reports on the plants, rituals and spells used against worms and the so-called <it>scantu </it>(fright) in some areas of Sicily. The work is based on ethnobotanical research carried out, prevalently, between 2002-2006, in some areas of Eastern, South-Eastern, North-Central and South-Central Sicily.</p> <p>Methods</p> <p>This research is based on dialogue. Senior 'healers' were contacted; furthermore, doctors, teachers, farmers and in general 'experts' with herbs and 'magic' rituals. Information was collected about the way the plants of folk medicine are prepared. The interviewees were also invited to recite prayers and spells against helminthiasis.</p> <p>Results</p> <p>The author has highlighted the importance of how, in some parts of Sicily, some ailments like helminthiasis and other correlated pathologies like <it>scantu </it>are 'treated' and, especially within the rural social classes, by folk medicine remedies, herbal practises, particular prayers, rituals and spells.</p> <p>Conclusion</p> <p>As regards health/illness, it should be noted that in the last ten years conventional medicine has provided very satisfactory results even resolving potentially mortal pathologies. However, in certain social classes, there is no real collaboration between conventional and folk medicine; so for some senior citizens, the 'healer' with his rituals and empirical and magical herbs is still the person to turn to for the 'cure' of particular ailments. Interest in these practises from ancestral heritage in an advanced country like Italy, is only relevant if the aim is to recoup a cultural identity which is already in decline.</p> <p>It is significant to report a piece: on 14 October 2007 the news on a well-known national Italian TV channel reported an interview with a 94 year-old man from Arbatax (Sardinia) referred to as a 'healer' because both his townspeople and others from all over the world go to him for his cures. He is not paid except in kind and has been known to cure St. Anthony's fire, burns, scalding and marine fungal infections, by smearing his saliva over the infected part and reciting 'special words'.</p
Cooperation and its evolution in growing systems with cultural reproduction
We explore the evolution of cooperation in the framework of the evolutionary
game theory using the prisoner's dilemma as metaphor of the problem. We present
a minimal model taking into account the growing process of the systems and
individuals with imitation capacity. We consider the topological structure and
the evolution of strategies decoupled instead of a coevolutionary dynamic. We
show conditions to build up a cooperative system with real topological
structures for any natural selection intensity. When the system starts to grow,
cooperation is unstable but becomes stable as soon as the system reaches a
small core of cooperators whose size increase when the intensity of natural
selection decreases. Thus, we reduce the emergence of cooperative systems with
cultural reproduction to justify a small initial cooperative structure that we
call cooperative seed. Otherwise, given that the system grows principally as
cooperator whose cooperators inhabit the most linked parts of the system, the
benefit-cost ratio required for cooperation evolve is drastically reduced
compared to the found in static networks. In this way, we show that in systems
whose individuals have imitation capacity the growing process is essential for
the evolution of cooperation.Comment: 16 pages, 2 figures. arXiv admin note: substantial text overlap with
arXiv:1111.247
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